Thursday, March 29, 2012

Vietnam: Launched H5N1 vaccine for poultry

Company central veterinary medicine (NAVETCO) will bring the H5N1 bird flu vaccine to market within the month 3/2012. This proceeding to completely replace the imported vaccines, to help Vietnam save hundreds of billion each year.

Science Council of the Veterinary Department, Ministry of Agriculture and Rural Development (MARD) has agreed to veterinary medicine company Central (NAVETCO) into vaccine production NAVET - Vifluvac. This is the result of research scientists Institute of Biotechnology, Ministry of Science and Technology, Ministry of Agriculture and Rural Development, Veterinary Drug Company from 2003 to Central today.


Acute disease prevention needs

Since 2003, when bird flu first appeared in Vietnam, the government has a policy to import bird flu vaccine in China. The cost for this amount to hundreds of billion each year. But this vaccine has a downside is not entirely consistent with the modified virus strains currently circulating in some northern provinces of Vietnam.

Due to these facts, the Institute of Biotechnology (BIOTECH) stood out to contact a number of organizations around the world to find the strain of H5N1 flu vaccine research for the purpose of vaccine production. On 11.3.2005, Institute of Biotechnology has received vaccine NIBRG - 14 from the National Institute of Standards and biologicals quality London (UK).

Immediately, the institute procedures to receive this strain, the same time, making registration of research projects produce bird flu vaccines (veterinary use).

According to the researchers, this really is a milestone in the field of vaccine research bird flu in Vietnam. After receiving the appropriate strain, the scientists of the Institute of Biotechnology has urgently embark on research work. These strains were generated by reverse genetics technology (artificial virus assembly containing the complete genome in which the H5 antigen gene is the "exclusive" has been modified by gene technology).

Success, the Ministry of Science and Technology Institute of Biotechnology has supported continuing to implement the project in period 2, from 2007 to 2008 with research and content assessment process production process bird flu vaccine H5N1.


Towards replace imported vaccines

A chicken farm in Xuan Mai (Hanoi) was chosen as the site to conduct the test step. 1500 chickens were divided into two lots, one lot is 1,000 vaccinated and Lot 500 is not a vaccine. After injection, blood periodically injected and not injected chickens were tested for effects of the vaccine, the results showed that 70-80% of vaccinated birds were created of antibodies by standard immune international standards.

As demand requires fact, in 2009, the Company has requested and was granted NAVETCO Ministry of Science and Technology, Ministry of Agriculture and Rural Development and support for the project plan "Production testing A/H5N1 flu vaccine emulsions oil to prevent the bird "at a cost of 1.5 billion project to produce the above test.

TS. Tran Xuan Hanh, head of the project - Deputy General Director of the Central Veterinary NAVETCO said, based on research results of the Institute of Biotechnology, with the help of the Ministry of Science and Technology, and Ministry of Agriculture Rural Development, made ​​the company NAVETCO project: "Production testing A/H5N1 flu vaccine oil emulsion to prevent disease in poultry." From there, gave birth to vaccines named NAVET - Vifluvac.

Currently, the project has successfully produced similar virus bird flu vaccine, strain NIBRG - 14 standard sterile and genetically stable. The project also has built a manufacturing process of influenza vaccine in poultry in industrial scale with capacity of 500,000 liters / batch (1,000,000 doses / batch). Vaccine storage length of 12 months from date of manufacture and stored at 2-8 0 C.

Thus, in the near future, Vietnam will likely be active vaccine offers the H5N1 bird flu in domestic demand and eventually completely replace imports.

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