Thursday, April 11, 2013

#H7N9 Gene Mutation To Resist Tamiflu Found in First 3 Patient Specimens Reported

4/11/13
Excerpt:

A gene mutation known to help influenza resist Tamiflu was found in the first of three H7N9 bird-flu patient specimens in China, sequence data show.

The flu virus from the patient in Shanghai has a mutation known as R292K that causes high-level resistance to the Roche Holding AG (ROG) pill and reduced sensitivity to a related drug from GlaxoSmithKline Plc (GSK) called Relenza, genetic sequence information posted on the website of the Global Initiative on Sharing Avian Influenza Data show. Subsequent H7N9 specimens from a patient in Shanghai and one in Anhui province don’t show the mutation. 
-snip-
The Chinese Center for Disease Control and Prevention in Beijing has studied H7N9 specimens and confirmed that the virus is sensitive to neuraminidase inhibitors, Tashiro said.

Full article:  http://www.bloomberg.com/news/2013-04-11/tamiflu-resistance-gene-in-h7n9-bird-flu-spurs-drug-tests.html

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